New research suggests that Pfizer’s COVID-19 vaccine can protect against a mutation found in two
easier-to-spread variants of the coronavirus that erupted in Britain and South Africa.
Those variants are causing global concern. They carry multiple mutations but share one in common that’s
believed to be the reason they are more contagious. Called N501Y, it is a slight alteration on one spot
of the spike protein that coats the virus.
Most of the vaccines being rolled out around the world train the body to recognize that spike protein and
fight it. Pfizer teamed with researchers from the University of Texas Medical Branch in Galveston for
laboratory tests to see if the mutation affected its vaccine’s ability to do so.
They used blood samples from 20 people who received the vaccine, made by Pfizer and its German partner
BioNTech, during a large study of the shots. Antibodies from those vaccine recipients successfully
fended off the virus in lab dishes, according to the study posted late Thursday on an online site for
researchers.
The study is preliminary and has not yet been reviewed by experts, a key step for medical research.
But "it was a very reassuring finding that at least this mutation, which was one of the ones people
are most concerned about, does not seem to be a problem" for the vaccine, said Pfizer chief
scientific officer Dr. Philip Dormitzer.
A similar vaccine by Moderna is being rolled out in the U.S. and Europe, and on Friday was cleared in
Britain. Moderna is doing similar testing to tell if its shot also works against the variants, as are
makers of other types of COVID-19 vaccines.
But Dr. Anthony Fauci, the top U.S. infectious disease expert, recently told The Associated Press that
vaccines are designed to recognize multiple parts of the spike protein, making it unlikely a single
mutation could be enough to block them. Still, testing is needed to be sure.
Viruses constantly undergo minor changes as they spread from person to person. Scientists have used these
slight modifications to track how the coronavirus has moved around the globe since it was first detected
in China about a year ago.
British scientists have said the variant found in the U.K. – which has become the dominant type in parts
of England — still seemed to be susceptible to vaccines. That mutant has now been found in the U.S. and
numerous other countries.
But the variant first discovered in South Africa has an additional mutation that has scientists on edge,
one named E484K.
The Pfizer study found that the vaccine appeared to work against 15 additional possible virus mutations,
but E484K wasn’t among those tested. Dormitzer said it is next on the list.
If the virus eventually mutates enough that the vaccine needs adjusting – much like flu shots are
adjusted most years – that tweaking the recipe wouldn’t be difficult for his company’s shot and similar
ones. Both the Pfizer-BioNTech and Moderna vaccines are made with a piece of the virus genetic code,
simple to switch, although it’s not clear what kind of additional testing regulators would require to
make such a change.
Dormitzer said this was only the beginning "of ongoing monitoring of virus changes to see if any of
them might impact on vaccine coverage."
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The Associated Press Health and Science Department receives support from the Howard Hughes Medical
Institute’s Department of Science Education. The AP is solely responsible for all content.